The immune response is essential to protect organisms from infection and an altered self.
An organism’s overall metabolic status is now recognized as an important and long-…

Inherited peroxisomal biogenesis disorders (PBDs) are characterized by the absence of
functional peroxisomes. They are caused by mutations of peroxisomal biogenesis factors …

Antimicrobial peptides (AMPs) are conserved cationic peptides which act both as defense
molecules of the host immune system and as regulators of the commensal microbiome. …

Maintenance of metabolic homeostasis requires adaption of gene regulation to the cellular
energy state via transcriptional regulators. Here, we identify a role of ceramide synthase (…

The gut has a central role in digestion and nutrient absorption, but it also serves in defending
against pathogens, engages in mutually beneficial interactions with commensals, and is a …

Forkhead transcription factors of the FoxO subfamily regulate gene expression programs
downstream of the insulin signaling network. It is less clear which proteins mediate …

The human LIPA gene encodes for the enzyme lysosomal acid lipase, which hydrolyzes
cholesteryl ester and triacylglycerol. Lysosomal acid lipase deficiency results in Wolman …

Mutations in peroxin (PEX) genes lead to loss of peroxisomes, resulting in the formation of
peroxisomal biogenesis disorders (PBDs) and early lethality. Studying PBDs and their animal …

Biochemical experiments in mammalian cells have linked Src family kinase activity to the
insulin signaling pathway. To explore the physiological link between Src and a central insulin …

Free or non-esterified fatty acids are the product of lipolysis of storage fat, ie triacylglyceroles.
When the amount of fat exceeds the capacity of lipid-storing organs, free fatty acids affect …