Background Estimating attributable mortality of ventilator-associated pneumonia has been
hampered by confounding factors, small sample sizes, and the difficulty of doing relevant …

Introduction Central venous catheterization is commonly used in critically ill patients and may
cause different complications, including infection. Although there are many studies about …

Rationale: Subglottic secretion drainage (SSD) appears to be effective in preventing
ventilator-associated pneumonia (VAP), primarily by reducing early-onset pneumonia; but it may not …

Introduction Extracorporeal circulation induces hemostatic alterations that lead to inflammatory
response (IR) and postoperative bleeding. Tranexamic acid (TA) reduces fibrinolysis and …

Background: It is known that β-lactam antibiotics exhibit time-dependent bactericidal activity.
Several studies have found continuous infusion of meropenem more effective than …

Objective Different genetic polymorphisms of human leukocyte antigen (HLA) have been
associated with the risk and prognosis of autoimmune and infectious diseases. The objectives …

Objectives: The “Pneumonia Zero” project is a nationwide multimodal intervention based on
the simultaneous implementation of a comprehensive evidence-based bundle measures to …

Objective A large proportion of patients infected with 2009 influenza A(H1N1) (A[H1N1]) are
obese. Obesity has been proposed as a risk factor influencing outcome in these patients. …

Objectives To define which variables upon ICU admission could be related to the presence
of coinfection using CHAID (Chi-squared Automatic Interaction Detection) analysis. Methods …

The standard mode of administration of piperacillin treatment is by intermittent infusion.
However, continuous infusion may be advantageous as β-lactam antibiotics exhibit time-…