User profiles for Laurent Renia
 | Laurent ReniaProfessor of Infectious Diseases, Lee Kong Chian School of Medicine, Nanyang … Verified email at ntu.edu.sg Cited by 41583 |
[HTML][HTML] The trinity of COVID-19: immunity, inflammation and intervention
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
the ongoing coronavirus disease 2019 (COVID-19) pandemic. Alongside investigations into …
the ongoing coronavirus disease 2019 (COVID-19) pandemic. Alongside investigations into …
[PDF][PDF] IRF4 transcription factor-dependent CD11b+ dendritic cells in human and mouse control mucosal IL-17 cytokine responses
Mouse and human dendritic cells (DCs) are composed of functionally specialized subsets, but
precise interspecies correlation is currently incomplete. Here, we showed that murine lung …
precise interspecies correlation is currently incomplete. Here, we showed that murine lung …
Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac–derived macrophages
Langerhans cells (LCs) are the dendritic cells (DCs) of the epidermis, forming one of the first
hematopoietic lines of defense against skin pathogens. In contrast to other DCs, LCs arise …
hematopoietic lines of defense against skin pathogens. In contrast to other DCs, LCs arise …
[HTML][HTML] Activated brain endothelial cells cross-present malaria antigen
SW Howland, CM Poh, L Rénia - PLoS pathogens, 2015 - journals.plos.org
In the murine model of cerebral malaria caused by P. berghei ANKA (PbA), parasite-specific
CD8 + T cells directly induce pathology and have long been hypothesized to kill brain …
CD8 + T cells directly induce pathology and have long been hypothesized to kill brain …
[HTML][HTML] Immunity, endothelial injury and complement-induced coagulopathy in COVID-19
In December 2019, a novel coronavirus was isolated from the respiratory epithelium of
patients with unexplained pneumonia in Wuhan, China. This pathogen, named severe acute …
patients with unexplained pneumonia in Wuhan, China. This pathogen, named severe acute …
[HTML][HTML] Effects of a major deletion in the SARS-CoV-2 genome on the severity of infection and the inflammatory response: an observational cohort study
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with
a 382-nucleotide deletion (∆382) in the open reading frame 8 (ORF8) region of the genome …
a 382-nucleotide deletion (∆382) in the open reading frame 8 (ORF8) region of the genome …
[HTML][HTML] Monkeypox: disease epidemiology, host immunity and clinical interventions
Monkeypox virus (MPXV), which causes disease in humans, has for many years been restricted
to the African continent, with only a handful of sporadic cases in other parts of the world. …
to the African continent, with only a handful of sporadic cases in other parts of the world. …
[HTML][HTML] Two linear epitopes on the SARS-CoV-2 spike protein that elicit neutralising antibodies in COVID-19 patients
Given the ongoing SARS-CoV-2 pandemic, identification of immunogenic targets against
the coronavirus spike glycoprotein will provide crucial advances towards the development of …
the coronavirus spike glycoprotein will provide crucial advances towards the development of …
[HTML][HTML] Whole blood immunophenotyping uncovers immature neutrophil-to-VD2 T-cell ratio as an early marker for severe COVID-19
SARS-CoV-2 is the novel coronavirus responsible for the current COVID-19 pandemic. Severe
complications are observed only in a small proportion of infected patients but the cellular …
complications are observed only in a small proportion of infected patients but the cellular …
[HTML][HTML] Serological approaches for COVID-19: epidemiologic perspective on surveillance and control
Since December 2019, the novel coronavirus, SARS-CoV-2, has garnered global attention
due to its rapid transmission, which has infected more than two million people worldwide. …
due to its rapid transmission, which has infected more than two million people worldwide. …