The dentate gyrus (DG) is a region in the mammalian brain critical for memory encoding
with a neuronal architecture and function that deviates considerably from other cortical areas. …

Granule cells (GCs) of the dentate gyrus use sparse encoding to perform redundancy reduction,
pattern separation, and novelty detection. One likely candidate mechanism to enforce …

A critical feature of neural networks is that they balance excitation and inhibition to prevent
pathological dysfunction. How this is achieved is largely unknown, although deficits in the …

Pattern separation is a process that minimizes overlap between patterns of neuronal activity
representing similar experiences. Theoretical work suggests that the dentate gyrus (DG) …

10.7554/eLife.42148.001 In epilepsy, brain networks generate pathological high-frequency
oscillations (pHFOs) during interictal periods. To understand how pHFOs differ from normal …

Neural dynamics preceding seizures are of interest because they may shed light on
mechanisms of seizure generation and could be predictive. In healthy animals, hippocampal …

In general, animal behavior can be described as the neuronal-driven sequence of reoccurring
postures through time. Most of the available current technologies focus on offline pose …

Pattern separation is a central concept in current theories of episodic memory: this
computation is thought to support our ability to avoid confusion between similar memories by …

The hippocampal dentate gyrus is an important relay conveying sensory information from
the entorhinal cortex to the hippocampus proper. During exploration, the dentate gyrus has …

Traumatic brain injury leads to cellular and circuit changes in the dentate gyrus, a gateway
to hippocampal information processing. Intrinsic granule cell firing properties and strong …