Cancer is a heterogeneous and complex disease. Tumors are formed by cancer cells and a
myriad of non-cancerous cell types that together with the extracellular matrix form the tumor …

In the past decade, single-cell transcriptomics has helped to uncover new cell types and
states and led to the construction of a cellular compendium of health and disease. Despite this …

Cells collectively determine biological functions by communicating with each other—both
through direct physical contact and secreted factors. Consequently, the local microenvironment …

Asymmetric subcellular mRNA localization allows spatial regulation of gene expression and
functional compartmentalization. In neurons, localization of specific mRNAs to neurites is …

The homeostasis of the gut epithelium relies upon continuous renewal and proliferation of
crypt-resident intestinal epithelial stem cells (IESCs). Wnt/β-catenin signaling is required for …

Eosinophils are an integral part of the gastrointestinal (GI) immune system that contribute to
homeostatic and inflammatory processes. Here, we investigated the existence of functional …

Objective Inflammatory bowel disease (IBD) is a multifactorial condition driven by genetic
and environmental risk factors. A genetic variation in the protein tyrosine phosphatase non-…

The spatial organization of cells within tissues is tightly linked to their biological function. Yet,
methods to probe the entire transcriptome of multiple native tissue microenvironments at …

Sequencing-based spatial transcriptomics (ST) methods allow unbiased capturing of RNA
molecules at barcoded spots, charting the distribution and localization of cell types and …

Single-cell transcriptomics has emerged as the preferred tool to define cell identity through
the analysis of gene expression signatures. However, there are limited studies that have …