[HTML][HTML] Cancer diagnosis and prognosis decoded by blood-based circulating microRNA signatures

D Madhavan, K Cuk, B Burwinkel, R Yang - Frontiers in genetics, 2013 - frontiersin.org
In the recent years, circulating microRNAs (miRNAs) have garnered a lot of attention and
interest in the field of disease biomarkers. With characteristics such as high stability, low cost, …

An RNA vaccine drives immunity in checkpoint-inhibitor-treated melanoma

…, M Diken, S Kreiter, H Haas, S Attig, R Rae, K Cuk… - Nature, 2020 - nature.com
Treating patients who have cancer with vaccines that stimulate a targeted immune response
is conceptually appealing, but cancer vaccine trials have not been successful in late-stage …

Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci

…, R Bisbjerg, MA Røder, P Iversen, H Brenner, K Cuk… - Nature …, 2018 - nature.com
Genome-wide association studies (GWAS) and fine-mapping efforts to date have identified
more than 100 prostate cancer (PrCa)-susceptibility loci. We meta-analyzed genotype data …

Discovery of common and rare genetic risk variants for colorectal cancer

…, SH Cho, CM Connolly, AJ Cross, K Cuk… - Nature …, 2019 - nature.com
To further dissect the genetic architecture of colorectal cancer (CRC), we performed whole-genome
sequencing of 1,439 cases and 720 controls, imputed discovered sequence variants …

Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer

…, I Coupier, A Cox, DG Cox, SS Cross, K Cuk… - Nature …, 2017 - nature.com
Most common breast cancer susceptibility variants have been identified through genome-wide
association studies (GWAS) of predominantly estrogen receptor (ER)-positive disease 1 . …

Circulating microRNAs in plasma as early detection markers for breast cancer

K Cuk, M Zucknick, J Heil, D Madhavan… - … journal of cancer, 2013 - Wiley Online Library
In recent years, circulating miRNAs have attracted a great deal of attention as promising novel
markers for various diseases. Here, we investigated their potential to serve as minimally …

Circulating microRNA biomarkers for lung cancer detection in Western populations

H Yu, Z Guan, K Cuk, H Brenner, Y Zhang - Cancer medicine, 2018 - Wiley Online Library
Lung cancer (LC) is a leading cause of cancer‐related death in the Western world. Patients
with LC usually have poor prognosis due to the difficulties in detecting tumors at early stages…

Circulating miRNAs as surrogate markers for circulating tumor cells and prognostic markers in metastatic breast cancer

D Madhavan, M Zucknick, M Wallwiener, K Cuk… - Clinical Cancer …, 2012 - AACR
Purpose: The use of circulating tumor cells (CTC) as a prognostic marker in metastatic breast
cancer (MBC) has been well established. However, their efficacy and accuracy are still …

[HTML][HTML] Circulating microRNA biomarkers for lung cancer detection in East Asian populations

H Yu, Z Guan, K Cuk, Y Zhang, H Brenner - Cancers, 2019 - mdpi.com
Background: Lung cancer (LC) is the leading cause of cancer-related death in Eastern Asia.
The prognosis of LC highly depends on tumor stages and early detection could substantially …

Plasma DNA integrity as a biomarker for primary and metastatic breast cancer and potential marker for early diagnosis

…, K Bents, M Zucknick, J Nees, S Schott, K Cuk… - Breast cancer research …, 2014 - Springer
Circulating or cell-free DNA (cfDNA) has been evaluated as a biomarker in many cancers
including breast cancer. In particular, integrity of cfDNA has been shown to be altered in …