User profiles for Karmela K. Chan
Karmela Kim ChanAssistant Professor of Medicine, Weill Cornell Medical College Verified email at hss.edu Cited by 381 |
Autoimmune complications of immunotherapy: pathophysiology and management
KK Chan, AR Bass - bmj, 2020 - bmj.com
Immune checkpoint inhibitors (ICIs) are monoclonal antibodies that target inhibitory molecules,
such as cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), programmed cell death …
such as cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), programmed cell death …
[HTML][HTML] Lower baseline autoantibody levels are associated with immune-related adverse events from immune checkpoint inhibition
…, D Jannat-Khah, QZ Li, G Vitone, KK Chan… - … for ImmunoTherapy of …, 2022 - ncbi.nlm.nih.gov
Methods This study used data from an oncologic clinical trial of adaptive dosing combination
ICI therapy in patients with advanced melanoma. Plasma was collected at baseline and 6 …
ICI therapy in patients with advanced melanoma. Plasma was collected at baseline and 6 …
Autoantibodies in patients with immune-related adverse events from checkpoint inhibitors: A systematic literature review
N Ghosh, KK Chan, B Jivanelli… - JCR: Journal of Clinical …, 2022 - journals.lww.com
Background Immune-related adverse events (irAEs) from immune checkpoint inhibitors (ICIs)
are sometimes associated with autoantibodies, but we do not know how frequently or …
are sometimes associated with autoantibodies, but we do not know how frequently or …
Checkpoint inhibitor–associated arthritis: A systematic review of case reports and case series
…, MD Tiongson, C Stewart, KK Chan… - JCR: Journal of …, 2021 - journals.lww.com
Objective We performed a systematic literature review to identify all reports of immune
checkpoint inhibitor–associated inflammatory arthritis to describe it phenotypically and …
checkpoint inhibitor–associated inflammatory arthritis to describe it phenotypically and …
Clonally expanded CD38hi cytotoxic CD8 T cells define the T cell infiltrate in checkpoint inhibitor–associated arthritis
…, AH Jonsson, MB Brenner, MA Postow, KK Chan… - Science …, 2023 - science.org
Immune checkpoint inhibitor (ICI) therapies used to treat cancer, such as anti–PD-1
antibodies, can induce autoimmune conditions in some individuals. The T cell mechanisms …
antibodies, can induce autoimmune conditions in some individuals. The T cell mechanisms …
Anticitrullinated peptide antibody epitope expansion and the HLA DRB1 'shared epitope'are less common in seropositive checkpoint inhibitor-induced inflammatory …
…, VP Bykerk, A Lakhanpal, D Rajesh, KK Chan… - RMD open, 2023 - rmdopen.bmj.com
Background Immune checkpoint inhibitors (ICI) can potentially cause ICI-inflammatory arthritis
(ICI-IA), which often resembles rheumatoid arthritis (RA). In this study, we examined the …
(ICI-IA), which often resembles rheumatoid arthritis (RA). In this study, we examined the …
Monitoring and management of the patient with immune checkpoint inhibitor-induced inflammatory arthritis: current perspectives
KK Chan, AR Bass - Journal of Inflammation Research, 2022 - Taylor & Francis
In this review, we draw from observational studies, treatment guidelines and our own clinical
experience to describe approaches to monitoring and management of immune checkpoint …
experience to describe approaches to monitoring and management of immune checkpoint …
[HTML][HTML] Activated osteoarthritis following immune checkpoint inhibitor treatment: an observational study
…, R Akruwala, AR Bass, KK Chan - … for immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy but can result in
toxicities, known as immune-related adverse events (irAEs), due to a hyperactivated immune …
toxicities, known as immune-related adverse events (irAEs), due to a hyperactivated immune …
Safety, tolerability, and efficacy of pirfenidone in patients with rheumatoid arthritis-associated interstitial lung disease: a randomised, double-blind, placebo-controlled …
…, LH Lancaster, LJ Crawford, K Chan… - The Lancet …, 2023 - thelancet.com
Background Interstitial lung disease is a known complication of rheumatoid arthritis, with a
lifetime risk of developing the disease in any individual of 7·7%. We aimed to assess the safety…
lifetime risk of developing the disease in any individual of 7·7%. We aimed to assess the safety…
2022 American College of Rheumatology Guideline for exercise, rehabilitation, diet, and additional integrative interventions for rheumatoid arthritis
…, A Anandarajah, K Carandang, KK Chan… - Arthritis & …, 2023 - Wiley Online Library
Objective To develop initial American College of Rheumatology (ACR) guidelines on the
use of exercise, rehabilitation, diet, and additional interventions in conjunction with disease‐…
use of exercise, rehabilitation, diet, and additional interventions in conjunction with disease‐…