User profiles for Karmela K. Chan

Karmela Kim Chan

Assistant Professor of Medicine, Weill Cornell Medical College
Verified email at hss.edu
Cited by 381

Autoimmune complications of immunotherapy: pathophysiology and management

KK Chan, AR Bass - bmj, 2020 - bmj.com
Immune checkpoint inhibitors (ICIs) are monoclonal antibodies that target inhibitory molecules,
such as cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), programmed cell death …

[HTML][HTML] Lower baseline autoantibody levels are associated with immune-related adverse events from immune checkpoint inhibition

…, D Jannat-Khah, QZ Li, G Vitone, KK Chan… - … for ImmunoTherapy of …, 2022 - ncbi.nlm.nih.gov
Methods This study used data from an oncologic clinical trial of adaptive dosing combination
ICI therapy in patients with advanced melanoma. Plasma was collected at baseline and 6 …

Autoantibodies in patients with immune-related adverse events from checkpoint inhibitors: A systematic literature review

N Ghosh, KK Chan, B Jivanelli… - JCR: Journal of Clinical …, 2022 - journals.lww.com
Background Immune-related adverse events (irAEs) from immune checkpoint inhibitors (ICIs)
are sometimes associated with autoantibodies, but we do not know how frequently or …

Checkpoint inhibitor–associated arthritis: A systematic review of case reports and case series

…, MD Tiongson, C Stewart, KK Chan… - JCR: Journal of …, 2021 - journals.lww.com
Objective We performed a systematic literature review to identify all reports of immune
checkpoint inhibitor–associated inflammatory arthritis to describe it phenotypically and …

Clonally expanded CD38hi cytotoxic CD8 T cells define the T cell infiltrate in checkpoint inhibitor–associated arthritis

…, AH Jonsson, MB Brenner, MA Postow, KK Chan… - Science …, 2023 - science.org
Immune checkpoint inhibitor (ICI) therapies used to treat cancer, such as anti–PD-1
antibodies, can induce autoimmune conditions in some individuals. The T cell mechanisms …

Anticitrullinated peptide antibody epitope expansion and the HLA DRB1 'shared epitope'are less common in seropositive checkpoint inhibitor-induced inflammatory …

…, VP Bykerk, A Lakhanpal, D Rajesh, KK Chan… - RMD open, 2023 - rmdopen.bmj.com
Background Immune checkpoint inhibitors (ICI) can potentially cause ICI-inflammatory arthritis
(ICI-IA), which often resembles rheumatoid arthritis (RA). In this study, we examined the …

Monitoring and management of the patient with immune checkpoint inhibitor-induced inflammatory arthritis: current perspectives

KK Chan, AR Bass - Journal of Inflammation Research, 2022 - Taylor & Francis
In this review, we draw from observational studies, treatment guidelines and our own clinical
experience to describe approaches to monitoring and management of immune checkpoint …

[HTML][HTML] Activated osteoarthritis following immune checkpoint inhibitor treatment: an observational study

…, R Akruwala, AR Bass, KK Chan - … for immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy but can result in
toxicities, known as immune-related adverse events (irAEs), due to a hyperactivated immune …

Safety, tolerability, and efficacy of pirfenidone in patients with rheumatoid arthritis-associated interstitial lung disease: a randomised, double-blind, placebo-controlled …

…, LH Lancaster, LJ Crawford, K Chan… - The Lancet …, 2023 - thelancet.com
Background Interstitial lung disease is a known complication of rheumatoid arthritis, with a
lifetime risk of developing the disease in any individual of 7·7%. We aimed to assess the safety…

2022 American College of Rheumatology Guideline for exercise, rehabilitation, diet, and additional integrative interventions for rheumatoid arthritis

…, A Anandarajah, K Carandang, KK Chan… - Arthritis & …, 2023 - Wiley Online Library
Objective To develop initial American College of Rheumatology (ACR) guidelines on the
use of exercise, rehabilitation, diet, and additional interventions in conjunction with disease‐…