Telomeres, the specialized nucleoprotein structures that comprise the ends of eukaryotic
chromosomes 1,2 , are essential for complete replication 3–5 , and regulation of their length …

Fig. 2. Two alternative models to solve the leading strand problem of telomere replication. It
is assumed that 3'overhangs are maintained at both chromosomal ends, as has been most …

Deletion of the telomerase catalytic subunit genetrt1 + in Schizosaccharomyces pombe results
in death for the majority of cells, but a subpopulation survives. Here it is shown that most …

Telomere replication is achieved through the combined action of the conventional DNA
replication machinery and the reverse transcriptase, telomerase. Telomere-binding proteins …

The alignment of homologous chromosomes during meiosis is essential for their recombination
and segregation. Telomeres form and protect the ends of eukaryotic linear chromosomes…

What really defines a telomere? Telomere literally is an amalgamation of the Greek words “telos,”
meaning end, and “mer,” meaning part. In practice, it refers to the extremities of linear …

Several considerations suggest that levels of the two major modes of double-strand break (DSB)
repair, homologous recombination (HR), and nonhomologous end joining (NHEJ), are …

A paramount role of telomeres is to prevent chromosome fusions. The fission yeast Taz1
protein regulates diverse telomere functions but is not essential for growth under stress-free …

Telomere protection and maintenance are accomplished through the coordinated actions of
telomere‐specific DNA binding proteins and their interacting partners. The fission yeast …

The notion that telomeres are essential for chromosome linearity stems from the existence
of two chief dangers: inappropriate DNA damage response (DDR) reactions that mistake …