User profiles for Jitao David Zhang
 | Jitao David ZhangA computational biologist in drug discovery Verified email at roche.com Cited by 4829 |
Comprehensive evaluation of transcriptome-based cell-type quantification methods for immuno-oncology
Motivation The composition and density of immune cells in the tumor microenvironment (TME)
profoundly influence tumor progression and success of anti-cancer therapies. Flow …
profoundly influence tumor progression and success of anti-cancer therapies. Flow …
KEGGgraph: a graph approach to KEGG PATHWAY in R and bioconductor
Motivation: KEGG PATHWAY is a service of Kyoto Encyclopedia of Genes and Genomes (KEGG),
constructing manually curated pathway maps that represent current knowledge on …
constructing manually curated pathway maps that represent current knowledge on …
An introduction to machine learning
…, J Siebourg‐Polster, B Steiert, JD Zhang - Clinical …, 2020 - Wiley Online Library
In the last few years, machine learning (ML) and artificial intelligence have seen a new
wave of publicity fueled by the huge and ever‐increasing amount of data and computational …
wave of publicity fueled by the huge and ever‐increasing amount of data and computational …
[HTML][HTML] MicroRNA-520/373 family functions as a tumor suppressor in estrogen receptor negative breast cancer by targeting NF-κB and TGF-β signaling pathways
MicroRNAs (miRNAs) as modulators of gene expression have been described to display both
tumor-promoting and tumor-suppressive functions. Although their role has been studied in …
tumor-promoting and tumor-suppressive functions. Although their role has been studied in …
MicroRNA-200c represses migration and invasion of breast cancer cells by targeting actin-regulatory proteins FHOD1 and PPM1F
MicroRNA-200c (miR-200c) has been shown to suppress epithelial-mesenchymal transition
(EMT), which is attributed mainly to targeting of ZEB1/ZEB2, repressors of the cell-cell …
(EMT), which is attributed mainly to targeting of ZEB1/ZEB2, repressors of the cell-cell …
Global microRNA level regulation of EGFR‐driven cell‐cycle protein network in breast cancer
S Uhlmann, H Mannsperger, JD Zhang… - Molecular systems …, 2012 - embopress.org
The EGFR‐driven cell‐cycle pathway has been extensively studied due to its pivotal role in
breast cancer proliferation and pathogenesis. Although several studies reported regulation of …
breast cancer proliferation and pathogenesis. Although several studies reported regulation of …
[PDF][PDF] 14-3-3ζ turns TGF-β's function from tumor suppressor to metastasis promoter in breast cancer by contextual changes of Smad partners from p53 to Gli2
…, Q Zhang, Y Saito, J Yao, H Wang, P Li, L Zhang… - Cancer cell, 2015 - cell.com
Transforming growth factor β (TGF-β) functions as a tumor suppressor in premalignant cells
but as a metastasis promoter in cancer cells. The dichotomous functions of TGF-β are …
but as a metastasis promoter in cancer cells. The dichotomous functions of TGF-β are …
White-to-brown metabolic conversion of human adipocytes by JAK inhibition
A Moisan, YK Lee, JD Zhang, CS Hudak, CA Meyer… - Nature cell …, 2015 - nature.com
The rising incidence of obesity and related disorders such as diabetes and heart disease
has focused considerable attention on the discovery of new therapeutics. One promising …
has focused considerable attention on the discovery of new therapeutics. One promising …
Localization‐and mutation‐dependent microRNA (miRNA) expression signatures in gastrointestinal stromal tumours (GISTs), with a cluster of co‐expressed miRNAs …
F Haller, A Von Heydebreck, JD Zhang… - The Journal of …, 2010 - Wiley Online Library
The molecular biology and clinical behaviour of gastrointestinal stromal tumours (GISTs)
are associated with their anatomical localization (stomach or intestine), and also with the …
are associated with their anatomical localization (stomach or intestine), and also with the …
[HTML][HTML] A novel orally available small molecule that inhibits hepatitis B virus expression
…, G Ottaviani, W Lu, NJ Parrott, JD Zhang… - Journal of …, 2018 - Elsevier
Background & Aims The hallmarks of chronic HBV infection are a high viral load (HBV DNA)
and even higher levels (>100-fold in excess of virions) of non-infectious membranous …
and even higher levels (>100-fold in excess of virions) of non-infectious membranous …