With the prevalence of end-stage renal disease rising 8% per annum globally 1 , there is an
urgent need for renal regenerative strategies. The kidney is a mesodermal organ that …

Directed differentiation of human pluripotent stem cells to kidney organoids brings the prospect
of drug screening, disease modelling and the generation of tissue for renal replacement. …

Human pluripotent stem cell (hPSC)-derived kidney organoids may facilitate disease modeling
and the generation of tissue for renal replacement. Long-term application, however, will …

Protein absorption in the intestine is mediated by proteases and brush‐border peptidases
together with peptide and amino acid transporters. Neutral amino acids are generated by a …

Direct reprogramming involves the enforced re-expression of key transcription factors to
redefine a cellular state. The nephron progenitor population of the embryonic kidney gives rise …

During development, distinct progenitors contribute to the nephrons versus the ureteric
epithelium of the kidney. Indeed, previous human pluripotent stem-cell-derived models of kidney …

Solute carrier family 1, member 1 (SLC1A1; also known as EAAT3 and EAAC1) is the major
epithelial transporter of glutamate and aspartate in the kidneys and intestines of rodents. …

While pluripotent stem cell-derived kidney organoids are now being used to model renal
disease, the proximal nephron remains immature with limited evidence for key functional solute …

Iminoglycinuria (IG) is an autosomal recessive abnormality of renal transport of glycine and
the imino acids proline and hydroxyproline, but the specific genetic defect(s) have not been …

Amino acid uptake in the intestine and kidney is mediated by a variety of amino acid
transporters. To understand the role of epithelial neutral amino acid uptake in whole body …