Glutamate neurotoxicity has been implicated in stroke, head trauma, multiple sclerosis and
neurodegenerative diseases. Although recent data show that cultured glioma cells secrete …

Background Activating mutations of EZH2, an epigenetic regulator, are present in approximately
20% of patients with follicular lymphoma. We investigated the activity and safety of …

Photosynthesis, a process catalysed by plants, algae and cyanobacteria converts sunlight
to energy thus sustaining all higher life on Earth. Two large membrane protein complexes, …

Interleukin-1β (IL-1β), a polypeptide immune mediator, is induced within the central nervous
system in response to a variety of pathological stimuli, including systemic infection, hypoxia, …

We conducted a phase I clinical trial of H3B-8800, an oral small molecule that binds Splicing
Factor 3B1 (SF3B1), in patients with MDS, CMML, or AML. Among 84 enrolled patients (42 …

Building project management requires effective coordination and collaboration between
multiple project members. It can be achieved through real time communication flow between all. …

Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults and the
second most common form of acute leukemia in children. Despite this, very little …

The purpose of investigation was to study the effect of intrathecal fentanyl on the onset and
duration of hyperbaric bupivacaine-induced spinal block in adult male patients. Fortythree …

Several lines of work have shown that astrocytes release glutamate in response to receptor
activation, which results in a modulation of local synaptic activity. Astrocytic glutamate …

BLM, the helicase mutated in Bloom syndrome, associates with topoisomerase 3α, RMI1 (RecQ-mediated
genome instability), and RPA, to form a complex essential for the maintenance …