Substance use disorders are more prevalent in schizophrenia, but the causal links between
both conditions remain unclear. Maternal immune activation (MIA) is associated with …

Animal behavioral tests are essential to understand the bases of neurologic and psychological
disorders, which can be evaluated by different methodological and experimental models. …

Relapse into drug use is a major problem faced by recovering addicts. In humans, an
intensification of the desire for the drug induced by environmental cues—incubation of drug craving…

Background Cannabis exposure during adolescence is associated with emotional and
motivational alterations that may entail an enhanced risk of developing psychiatric disorders. In …

Rationale and objective Pain-related factors increase the risk for opioid addiction, and pain
may function as a negative reinforcer to increase opioid taking and seeking. However, …

… Javier Orihuel and Roberto Capellán performed the research and statistical analyses. …
Javier Orihuel wrote the first draft of the manuscript with the help of Alejandro Higuera-Matas. …

We previously demonstrated a role of piriform cortex (Pir) in relapse to fentanyl seeking after
food choice-induced voluntary abstinence. Here, we used this model to further study the …

The orbitofrontal cortex (OFC) is a key brain region for decision-making, action control and
impulsivity. Quite notably, previous research has identified a double dissociation regarding …

The orbitofrontal cortex (OFC) and piriform cortex (Pir) play a role in fentanyl relapse after
food choice-induced voluntary abstinence, a procedure mimicking abstinence because of …

Although cocaine abuse is up to three times more frequent among schizophrenic patients, it
remains unclear why this should be the case and whether sex influences this relationship. …