Unicellular organisms such as yeasts require a single cyclin-dependent kinase, Cdk1, to
drive cell division 1 . In contrast, mammalian cells are thought to require the sequential …

Alternative splicing is an important mechanism for controlling gene expression. It allows large
proteomic complexity from a limited number of genes. An interplay of cis-acting sequences …

Pre-mRNA splicing is a predominantly co-transcriptional event which involves a large number
of essential splicing factors 1,2 . Within the mammalian cell nucleus, most splicing factors …

hnRNP A1 is an RNA-binding protein involved in various aspects of RNA processing. Use
of an in vivo cross-linking and immunoprecipitation protocol to find hnRNP A1 RNA targets …

The opposing effects of SF2/ASF and heterogeneous nuclear ribonucleoprotein (hnRNP)
A1 influence alternative splicing in vitro. SF2/ASF or hnRNP A1 complementary DNAs were …

The SR proteins constitute a large family of nuclear phosphoproteins required for constitutive
pre-mRNA splicing. These factors also have global, concentration-dependent effects on …

The Nonsense-mediated mRNA decay (NMD) pathway selectively degrades mRNAs
harboring premature termination codons (PTCs) but also regulates the abundance of a large …

SR proteins are required for constitutive pre-mRNA splicing and also regulate alternative
splice site selection in a concentration-dependent manner. They have a modular structure that …

MicroRNAs (miRNAs) are important regulators of gene expression that bind complementary
target mRNAs and repress their expression. Precursor miRNA molecules undergo nuclear …

The Ser-Arg-rich (SR) proteins comprise a large family of nuclear phosphoproteins that are
required for constitutive and alternative splicing. A subset of SR proteins shuttles …