Nearly all patients with small cell lung cancer (SCLC) eventually relapse with chemoresistant
disease. The molecular mechanisms driving chemoresistance in SCLC remain un-…

Visualizing and summarizing data from genomic studies continues to be a challenge. Here,
we introduce the GenVisR package to addresses this challenge by providing highly …

Here we report targeted sequencing of 83 genes using DNA from primary breast cancer
samples from 625 postmenopausal (UBC-TAM series) and 328 premenopausal (MA12 trial) …

Large-scale cancer genomics discovery projects such as The Cancer Genome Atlas (TCGA)
and the International Cancer Genome Consortium (ICGC) have systematically …

Purpose Following automated variant calling, manual review of aligned read sequences is
required to identify a high-quality list of somatic variants. Despite widespread use in …

The interpretation of variants in cancer is frequently focused on direct protein coding alterations.
However, this analysis strategy excludes somatic mutations in non-coding regions of the …

Somatic mutations within non-coding regions and even exons may have unidentified
regulatory consequences that are often overlooked in analysis workflows. Here we present …

The negative effect of advanced female age on fertility and offspring health is well understood.
In comparison, much less is known about the implications of male age on fertility, with …

Osteosarcoma is a rare disease in children but is one of the most common cancers in adult
large breed dogs. The mutational landscape of both the primary and pulmonary metastatic …

Background Mixed fibrolamellar hepatocellular carcinoma (mFL-HCC) is a rare liver tumor
defined by the presence of both pure FL-HCC and conventional HCC components, …