The UK Biobank project is a prospective cohort study with deep genetic and phenotypic
data collected on approximately 500,000 individuals from across the United Kingdom, aged …

The genetic make-up of an individual contributes to the susceptibility and response to viral
infection. Although environmental, clinical and social factors have a role in the chance of …

Many common variants have been associated with hematological traits, but identification of
causal genes and pathways has proven challenging. We performed a genome-wide …

The UK Biobank project is a large prospective cohort study of ~500,000 individuals from across
the United Kingdom, aged between 40-69 at recruitment. A rich variety of phenotypic and …

Many existing cohorts contain a range of relatedness between genotyped individuals, either
by design or by chance. Haplotype estimation in such cohorts is a central step in many …

Background Understanding the genetic basis of airflow obstruction and smoking behaviour
is key to determining the pathophysiology of chronic obstructive pulmonary disease (COPD). …

Polygenic risk scores (PRSs) increasingly predict complex traits; however, suboptimal
performance in non-European populations raise concerns about clinical applications and health …

The UK Biobank (UKB) has recently released genotypes on 152,328 individuals together
with extensive phenotypic and lifestyle information. We present a new phasing method, …

Motivation: Mate pair protocols add to the utility of paired-end sequencing by boosting the
genomic distance spanned by each pair of reads, potentially allowing larger repeats to be …

This paper describes the R package mhsmm which implements estimation and prediction
methods for hidden Markov and semi-Markov models for multiple observation sequences. …