Much of what we know about the early stages of T cell activation has been obtained from
studies of T cells interacting with glass-supported lipid bilayers that favor imaging but are …

Supported lipid bilayers (SLBs) are one of the most common cell-membrane model systems
to study cell-cell interactions. Nickel-chelating lipids are frequently used to functionalize the …

T cells use finger-like protrusions called ‘microvilli’ to interrogate their targets, but why they
do so is unknown. To form contacts, T cells must overcome the highly charged, barrier-like …

Soluble aggregates of the microtubule-associated protein tau have been challenging to
assemble and characterize, despite their important role in the development of tauopathies. We …

Background Aortic dissection (AoD) is a rare complication of pregnancy. Women with connective
tissue disorders (CTD) are at increased risk. Our aim was to detail the clinical features, …

The electrophoretic behavior of mucoproteins isolated from perchloric acid filtrates of human
plasma has been studied over the pH range of 2 to 8.4. There are at least 3 electrophoretic …

The failure of the health service to meet the needs of looked after children is further emphasised
in the following article. Here, Mary Mather, Jane Humphrey and Jenny Robson argue …

Antigen receptors play a central role in determining whether an immune response is required.
The remarkable diversity of their extracellular domains allows them to detect unfamiliar …

Cell-cell contacts often underpin signaling between cells. For immunology, the binding of a
T cell receptor to an antigen-presenting pMHC initiates downstream signaling and an …

… In this beautiful book, Sarah Jane Humphrey explains the techniques of the botanical
artist but also introduces ideas for scientific illustration, so that the illustrator has a fuller …