All cells undergo rapid remodeling of their actin networks to regulate such critical processes
as endocytosis, cytokinesis, cell polarity, and cell morphogenesis. These events are driven …

Formin proteins participate in a wide range of cytoskeletal processes in all eukaryotes. The
defining feature of formins is a highly conserved ∼400 residue region, the Formin Homology-…

Many eukaryotic cell types undergo size-dependent cell cycle transitions controlled by the
ubiquitous cyclin-dependent kinase Cdk1 (refs 1 ). The proteins that control Cdk1 activity are …

Formins have conserved roles in cell polarity and cytokinesis and directly nucleate actin
filament assembly through their FH2 domain. Here, we define the active region of the yeast …

A critical microtubule (MT) polarization event in cell migration is the Rho/mDia-dependent
stabilization of a subset of MTs oriented toward the direction of migration. Although mDia …

The tumor suppressor protein adenomatous polyposis coli (APC) regulates cell protrusion
and cell migration, processes that require the coordinated regulation of actin and microtubule …

Formins are conserved proteins that nucleate actin assembly and tightly associate with the
fast growing barbed ends of actin filaments to allow insertional growth. Most organisms …

Adenomatous polyposis coli (APC) protein is a large tumor suppressor that is truncated in
most colorectal cancers. The carboxyl-terminal third of APC protein mediates direct …

Cyclase-associated protein (CAP), also called Srv2 in Saccharomyces cerevisiae, is a
conserved actin monomer-binding protein that promotes cofilin-dependent actin turnover in vitro …

Working in concert, multiple actin-binding proteins regulate the dynamic turnover of actin
networks. Here, we define a novel function for the conserved actin-binding protein twinfilin, …