Exosomes are endosome-derived nanovesicles involved in cellular communication. They
are natural nanocarriers secreted by various cells, making them suitable candidates for …

The limitations of conventional therapeutic drugs necessitate the importance of developing
novel therapeutics to treat diverse diseases. Conventional drugs have poor blood circulation …

Fluctuations in the intracellular chloride ion concentration, mediated by synthetic ion
transporters, have been known to induce cytotoxicity in cells by disrupting ionic homeostasis. …

Obtaining atomistic resolution of drug unbinding from a protein is a much sought-after
experimental and computational challenge. We report the unbinding dynamics of the anticancer …

Secretion of extracellular polymeric substances (EPSs) by growing bacteria is an integral
part of forming biofilm-like structures. In such dense systems, mechanical interactions among …

Longstanding mechanistic questions about the role of protecting osmolyte trimethylamine N-oxide
(TMAO) that favors protein folding and the denaturing osmolyte urea are addressed by …

It is currently the consensus belief that protective osmolytes such as trimethylamine N-oxide
(TMAO) favor protein folding by being excluded from the vicinity of a protein, whereas …

Previously observed effects of rifampicin and chloramphenicol indicate that transcription and
translation activity strongly affect the coarse spatial organization of the bacterial cytoplasm. …

In Escherichia coli, ribosomes concentrate near the cylindrical wall and at the endcaps,
whereas the chromosomal DNA segregates in the more centrally located nucleoid. A simple …

Recently, surface-enhanced Raman scattering nanoprobes have shown tremendous potential
in oncological imaging owing to the high sensitivity and specificity of their fingerprint-like …