User profiles for Jacob Hanna
 | Jacob H. Hanna - MD PhDProfessor of Pluripotent Stem Cell Biology & Synthetic Embryology, Weizmann Institute of … Verified email at weizmann.ac.il Cited by 38641 |
Derivation of novel human ground state naive pluripotent stem cells
Mouse embryonic stem (ES) cells are isolated from the inner cell mass of blastocysts, and can
be preserved in vitro in a naive inner-cell-mass-like configuration by providing exogenous …
be preserved in vitro in a naive inner-cell-mass-like configuration by providing exogenous …
Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin
It has recently been demonstrated that mouse and human fibroblasts can be reprogrammed
into an embryonic stem cell–like state by introducing combinations of four transcription …
into an embryonic stem cell–like state by introducing combinations of four transcription …
CXCL12 expression by invasive trophoblasts induces the specific migration of CD16– human natural killer cells
In the maternal decidua, natural killer (NK) cells, characterized by lack of CD16, are found in
direct contact with the fetal extravillous trophoblasts (EVTs). It is yet unknown which factors …
direct contact with the fetal extravillous trophoblasts (EVTs). It is yet unknown which factors …
Complexes of HLA-G protein on the cell surface are important for leukocyte Ig-like receptor-1 function
The nonclassical class I MHC molecule HLA-G is selectively expressed on extravillous
cytotrophoblast cells at the maternal-fetal interface during pregnancy. HLA-G can inhibit the …
cytotrophoblast cells at the maternal-fetal interface during pregnancy. HLA-G can inhibit the …
Histone H3K27ac separates active from poised enhancers and predicts developmental state
Developmental programs are controlled by transcription factors and chromatin regulators,
which maintain specific gene expression programs through epigenetic modification of the …
which maintain specific gene expression programs through epigenetic modification of the …
Genome-scale DNA methylation maps of pluripotent and differentiated cells
DNA methylation is essential for normal development 1 , 2 , 3 and has been implicated in
many pathologies including cancer 4 , 5 . Our knowledge about the genome-wide distribution …
many pathologies including cancer 4 , 5 . Our knowledge about the genome-wide distribution …
m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation
…, M Zerbib, I Maza, Y Rechavi, R Massarwa, S Hanna… - Science, 2015 - science.org
Naïve and primed pluripotent states retain distinct molecular properties, yet limited knowledge
exists on how their state transitions are regulated. Here, we identify Mettl3, an N 6 -…
exists on how their state transitions are regulated. Here, we identify Mettl3, an N 6 -…
Decidual NK cells regulate key developmental processes at the human fetal-maternal interface
Human CD56 bright NK cells accumulate in the maternal decidua during pregnancy and are
found in direct contact with fetal trophoblasts. Several mechanisms have been proposed to …
found in direct contact with fetal trophoblasts. Several mechanisms have been proposed to …
Dissecting direct reprogramming through integrative genomic analysis
Somatic cells can be reprogrammed to a pluripotent state through the ectopic expression of
defined transcription factors. Understanding the mechanism and kinetics of this …
defined transcription factors. Understanding the mechanism and kinetics of this …
[HTML][HTML] Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency
Pluripotent cells can be derived from fibroblasts by ectopic expression of defined transcription
factors. A fundamental unresolved question is whether terminally differentiated cells can …
factors. A fundamental unresolved question is whether terminally differentiated cells can …