Aging is a pleiotropic process affecting many aspects of mammalian physiology. Mammals
are composed of distinct cell type identities and tissue environments, but the influence of …

Partial pluripotent reprogramming can reverse features of aging in mammalian cells, but the
impact on somatic identity and the necessity of individual reprogramming factors remain …

Annotating cell identities is a common bottleneck in the analysis of single-cell genomics
experiments. Here, we present scNym, a semisupervised, adversarial neural network that learns …

Murine muscle stem cells (MuSCs) experience a transition from quiescence to activation
that is required for regeneration, but it remains unknown if the trajectory and dynamics of …

Cell populations display heterogeneous and dynamic phenotypic states at multiple scales.
Similar to molecular features commonly used to explore cell heterogeneity, cell behavior is a …

Skeletal muscle experiences a decline in lean mass and regenerative potential with age, in
part due to intrinsic changes in progenitor cells. However, it remains unclear how age-…

Cells in culture display diverse motility behaviors that may reflect differences in cell state and
function, providing motivation to discriminate between different motility behaviors. Current …

Annotating cell identities is a common bottleneck in the analysis of single cell genomics
experiments. Here, we present scNym, a semi-supervised, adversarial neural network that …

Transient induction of pluripotent reprogramming factors has been reported to reverse some
features of aging in mammalian cells and tissues. However, the impact of transient …

Background Aging is a pleiotropic process affecting many aspects of organismal and cellular
physiology. Mammalian organisms are composed of a constellation of distinct cell type and …