User profiles for Iris N. Kalka
 | Iris N. KalkaWeizmann Institute of Science Verified email at weizmann.ac.il Cited by 2618 |
Environment dominates over host genetics in shaping human gut microbiota
Human gut microbiome composition is shaped by multiple factors but the relative contribution
of host genetics remains elusive. Here we examine genotype and microbiome data from …
of host genetics remains elusive. Here we examine genotype and microbiome data from …
Phage-display immunoprecipitation sequencing of the antibody epitope repertoire in inflammatory bowel disease reveals distinct antibody signatures
Inflammatory bowel diseases (IBDs), eg, Crohn's disease (CD) and ulcerative colitis (UC),
are chronic immune-mediated inflammatory diseases. A comprehensive overview of an IBD-…
are chronic immune-mediated inflammatory diseases. A comprehensive overview of an IBD-…
Population-wide diversity and stability of serum antibody epitope repertoires against human microbiota
Serum antibodies can recognize both pathogens and commensal gut microbiota. However,
our current understanding of antibody repertoires is largely based on DNA sequencing of the …
our current understanding of antibody repertoires is largely based on DNA sequencing of the …
Systemic antibody responses against human microbiota flagellins are overrepresented in chronic fatigue syndrome patients
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disease with
an unclear etiology and pathogenesis. Both an involvement of the immune system and gut …
an unclear etiology and pathogenesis. Both an involvement of the immune system and gut …
Cross-reactive antibodies against human coronaviruses and the animal coronavirome suggest diagnostics for future zoonotic spillovers
…, RD Mazor, IN Kalka, L Stoler-Barak, N Nathan… - Science …, 2021 - science.org
The spillover of animal coronaviruses (aCoVs) to humans has caused SARS, MERS, and
COVID-19. Although antibody responses displaying cross-reactivity between SARS-CoV-2 and …
COVID-19. Although antibody responses displaying cross-reactivity between SARS-CoV-2 and …
Cross-reactive antibody responses against SARS-CoV-2 and seasonal common cold coronaviruses
Beyond SARS-CoV-2, six more coronaviruses infect humans (hCoVs), four of which cause
only mild symptoms (seasonal/common cold hCoVs) 12 . Previous exposures to seasonal …
only mild symptoms (seasonal/common cold hCoVs) 12 . Previous exposures to seasonal …
Allergenic food protein consumption is associated with systemic IgG antibody responses in non-allergic individuals
Although food-directed immunoglobulin E (IgE) has been studied in the context of allergies,
the prevalence and magnitude of IgG responses against dietary antigens are incompletely …
the prevalence and magnitude of IgG responses against dietary antigens are incompletely …
[HTML][HTML] BIPS—A code base for designing and coding of a Phage ImmunoPrecipitation Oligo Library
BIPS (Build Phage ImmunoPrecipitation Sequencing library) is a software that converts a list
of proteins into a custom DNA oligonucleotide library for the PhIP-Seq system. The tool …
of proteins into a custom DNA oligonucleotide library for the PhIP-Seq system. The tool …
In-depth characterization of the serum antibody epitope repertoire in inflammatory bowel disease using phage-displayed immunoprecipitation sequencing
Inflammatory bowel diseases (IBD), eg Crohn’s disease (CD) and ulcerative colitis (UC), are
chronic immune-mediated inflammatory diseases. A comprehensive overview of an IBD-…
chronic immune-mediated inflammatory diseases. A comprehensive overview of an IBD-…
Phage display sequencing reveals that genetic, environmental, and intrinsic factors influence variation of human antibody epitope repertoire
Phage-displayed immunoprecipitation sequencing (PhIP-seq) has enabled high-throughput
profiling of human antibody repertoires. However, a comprehensive overview of …
profiling of human antibody repertoires. However, a comprehensive overview of …