INFECTION of fibroblasts by avian sarcoma virus (ASV) leads to neoplastic transformation
of the host cell. Genetic analyses have implicated specific viral genes in the transforming …

Background Lung adenocarcinomas from patients who respond to the tyrosine kinase inhibitors
gefitinib (Iressa) or erlotinib (Tarceva) usually harbor somatic gain-of-function mutations …

Determining the genetic basis of cancer requires comprehensive analyses of large collections
of histopathologically well-classified primary tumours. Here we report the results of a …

President Obama has announced a research initiative that aims to accelerate progress
toward a new era of precision medicine, with a near-term focus on cancers and a longer …

We have asked whether oncogenesis by the mouse mammary tumor virus (MMTV), a slowly
oncogenic retrovirus, involves integration of viral DNA within a certain region of the host …

Fifteen years ago, the drive to study retroviruses was rooted principally in the traditional
goal of using animal models to understand human cancer. The historical importance of …

The Genomic Data Commons will initially house raw genomic data and diagnostic, histologic,
and clinical outcome data from National Cancer Institute–funded projects. A harmonization …

Somatic alterations in cellular DNA underlie almost all human cancers 1 . The prospect of
targeted therapies 2 and the development of high-resolution, genome-wide approaches 3 , 4 , …

Somatic mutations in the tyrosine kinase (TK) domain of the epidermal growth factor
receptor (EGFR) gene are reportedly associated with sensitivity of lung cancers to gefitinib (Iressa), …

A domain of DNA designated N-myc is amplified 20- to 140-fold in human neuroblastoma
cell lines but not in cell lines from other tumor types. N-myc has now been found to be …