In image-based profiling, software extracts thousands of morphological features of cells
from multi-channel fluorescence microscopy images, yielding single-cell profiles that can be …

Genetic and chemical perturbations impact diverse cellular phenotypes, including multiple
indicators of cell health. These readouts reveal toxicity and antitumorigenic effects relevant to …

The identification of genetic and chemical perturbations with similar impacts on cell morphology
can elucidate compounds’ mechanisms of action or novel regulators of genetic pathways…

… Shafqat-Abbasi et al. developed a method to analyse how … adopt two distinct migration modes,
which Shafqat-Abbasi et al. termed ’… Shafqat-Abbasi et al.’s method provides an analytical …

Cellular exposure to free fatty acids (FFAs) is implicated in the pathogenesis of obesity-associated
diseases. However, there are no scalable approaches to comprehensively assess the …

Cell migration is heavily interconnected with plasma membrane protrusion and retraction (collectively
termed “membrane dynamics”). This makes it difficult to distinguish regulatory …

Quantitative microscopy is a powerful method for performing phenotypic screens, from which
image-based profiling can extract a wealth of information, termed profiles. These profiles …

Heterogeneous and dynamic single cell migration behaviours arise from a complex multi-scale
signalling network comprising both molecular components and macromolecular modules…

Quantitative microscopy is a powerful method for performing phenotypic screens from which
image‐based profiling can extract a wealth of information, termed profiles. These profiles …

Widespread sequencing has yielded thousands of missense variants predicted or confirmed
as disease-causing. This creates a new bottleneck: determining the functional impact of …