Structural variants (SVs) can contribute to oncogenesis through a variety of mechanisms.
Despite their importance, the identification of SVs in cancer genomes remains challenging. …

Chromosome conformation capture (3C) assays are used to map chromatin interactions
genome-wide. Chromatin interaction maps provide insights into the spatial organization of …

The mammalian HoxD cluster lies between two topologically associating domains (TADs)
matching distinct enhancer-rich regulatory landscapes. During limb development, the …

Translation regulation is critical for early mammalian embryonic development 1 . However,
previous studies had been restricted to bulk measurements 2 , precluding precise …

Chromosome folding is modulated as cells progress through the cell cycle. During mitosis,
condensins fold chromosomes into helical loop arrays. In interphase, the cohesin complex …

Background Hi-C is currently the most widely used assay to investigate the 3D organization
of the genome and to study its role in gene regulation, DNA replication, and disease. …

A major challenge in biology is to understand how complex gene expression patterns are
encoded in the genome. While transcriptional enhancers have been studied extensively, few …

The inactive X chromosome (Xi) in female mammals adopts an atypical higher-order chromatin
structure, manifested as a global loss of local topologically associated domains (TADs), A/…

Background: Hi-C is currently the most widely used assay to investigate the 3D organization
of the genome and to study its role in gene regulation, DNA replication, and disease. …

In light of the numerous studies identifying post-transcriptional regulators on the surface of
the endoplasmic reticulum (ER), we asked whether there are factors that regulate …