Global insights into cellular organization and genome function require comprehensive
understanding of the interactome networks that mediate genotype–phenotype relationships 1 , 2 . …

Background Recent advances in proteomics technologies such as two-hybrid, phage
display and mass spectrometry have enabled us to create a detailed map of biomolecular …

Cytoscape is a free software package for visualizing, modeling and analyzing molecular and
genetic interaction networks. This protocol explains how to use Cytoscape to analyze the …

Pathway enrichment analysis helps researchers gain mechanistic insight into gene lists
generated from genome-scale (omics) experiments. This method identifies biological pathways …

Cytoscape is open-source software for integration, visualization and analysis of biological
networks. It can be extended through Cytoscape plugins, enabling a broad community of …

Biological Pathway Exchange (BioPAX) is a standard language to represent biological
pathways at the molecular and cellular level and to facilitate the exchange of pathway data. The …

A major goal of proteomics is the complete description of the protein interaction network
underlying cell physiology. A large number of small scale and, more recently, large-scale …

The recent abundance of genome sequence data has brought an urgent need for systematic
proteomics to decipher the encoded protein networks that dictate cellular function 1 . To …

GeneMANIA ( http://www.genemania.org ) is a flexible, user-friendly web interface for
generating hypotheses about gene function, analyzing gene lists and prioritizing genes for …

In Saccharomyces cerevisiae, more than 80% of the ∼6200 predicted genes are nonessential,
implying that the genome is buffered from the phenotypic consequences of genetic …