Microglia maintain homeostasis in the brain, but whether aberrant microglial activation can
cause neurodegeneration remains controversial. Here, we use transcriptome profiling to …

The signalling pathways controlling both the evolution and development of language in the
human brain remain unknown. So far, the transcription factor FOXP2 (forkhead box P2) is the …

To gain insight into how mutant huntingtin (mHtt) CAG repeat length modifies Huntington's
disease (HD) pathogenesis, we profiled mRNA in over 600 brain and peripheral tissue …

The regenerative capacity of the injured CNS in adult mammals is severely limited, yet axons
in the peripheral nervous system (PNS) regrow, albeit to a limited extent, after injury. We …

Transcriptional dysregulation has emerged as a core pathologic feature of Huntington's
disease (HD), one of several triplet-repeat disorders characterized by movement deficits and …

Understanding human-specific patterns of brain gene expression and regulation can
provide key insights into human brain evolution and speciation. Here, we use next-generation …

Aging is the predominant risk factor for neurodegenerative diseases. One key phenotype as
the brain ages is an aberrant innate immune response characterized by proinflammation. …

Peripheral nerves are easily damaged, resulting in loss of motor and sensory function.
Recovery of motor and sensory function after peripheral nerve injury is suboptimal, even after …

… Fuying Gao , Fuying Gao … Fogel, Eric Wexler, Amanda Wahnich, Tara Friedrich, Chandran
Vijayendran, Fuying Gao, Neelroop Parikshak, Genevieve Konopka, Daniel H. Geschwind, …

Contrary to the long-held belief that DNA methylation of terminally differentiated cells is
permanent and essentially immutable, post-mitotic neurons exhibit extensive DNA demethylation…