Abstract Structure–function studies have defined two classes of viral membrane-fusion proteins
that have radically different architectures but adopt a similar overall 'hairpin' conformation …

The crystallographically determined structure of a soluble fragment from the major envelope
protein of a flavivirus reveals an unusual architecture. The flat, elongated dimer extends in a …

Highlights • Virion heterogeneity arising from incomplete maturation and particle dynamics. •
Heterogeneous particle populations may synergistically expand flavivirus tropism. • Partially …

The SARS-CoV-2 Omicron variant was first identified in November 2021 in Botswana and
South Africa 1 , 2 – 3 . It has since spread to many countries and is expected to rapidly become …

Chikungunya virus (CHIKV) is an emerging mosquito-borne alphavirus that has caused
widespread outbreaks of debilitating human disease in the past five years 1 . CHIKV invasion of …

Coronaviruses cause respiratory tract infections in humans and outbreaks of deadly pneumonia
worldwide. Infections are initiated by the transmembrane spike (S) glycoprotein, which …

Background A chikungunya virus outbreak of unprecedented magnitude is currently ongoing
in Indian Ocean territories. In Réunion Island, this alphavirus has already infected about …

The animal reservoir of SARS-CoV-2 is unknown despite reports of SARS-CoV-2-related
viruses in Asian Rhinolophus bats 1 , 2 , 3 – 4 , including the closest virus from R. affinis, …

We report the crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus,
a major human pathogen, to 2.8-Å resolution. This enzyme is a key target for developing …

The structure of a large fragment of the p50 subunit of the human transcription factor NF-κB,
bound as a homodimer to DNA, reveals that the Rel-homology region has two β-barrel …