The endoplasmic reticulum ( ER ) is a membranous intracellular organelle and the first
compartment of the secretory pathway. As such, the ER contributes to the production and folding …

Stress induced by the accumulation of unfolded proteins in the endoplasmic reticulum (ER)
is a feature of specialized secretory cells and is also observed in many diseases, including …

Stress induced by accumulation of misfolded proteins in the endoplasmic reticulum is observed
in many physiological and pathological conditions. To cope with endoplasmic reticulum …

Hepatocellular carcinoma (HCC) is the most common primary liver malignancy. Here, we
performed high-resolution copy-number analysis on 125 HCC tumors and whole-exome …

Phagocytosis is a key aspect of our innate ability to fight infectious diseases. In this study,
we have found that fusion of the endoplasmic reticulum (ER) with the macrophage …

The endoplasmic reticulum (ER) has emerged as a major site of cellular homeostasis regulation,
particularly in the unfolded protein response, which is being found to play a major role …

Mitogen-activated protein kinase dual-specificity phosphatase-1 (also called MKP-1, DUSP1,
ERP, CL100, HVH1, PTPN10, and 3CH134) is a member of the threonine-tyrosine dual-…

The global epidemic of obesity has been accompanied by a rising burden of non-alcoholic
fatty liver disease (NAFLD), with manifestations ranging from simple steatosis to non-…

Tumor cells are often exposed to intrinsic and external factors that alter protein homeostasis,
thus producing endoplasmic reticulum (ER) stress. To cope with this, cells evoke an …

To verify the genome annotation and to create a resource to functionally characterize the
proteome, we attempted to Gateway-clone all predicted protein-encoding open reading frames (…