User profiles for Els Pardon
 | Els Pardonvrije universiteit brussel Verified email at vub.ac.be Cited by 16355 |
Crystal structure of the β2 adrenergic receptor–Gs protein complex
G protein-coupled receptors (GPCRs) are responsible for the majority of cellular responses
to hormones and neurotransmitters as well as the senses of sight, olfaction and taste. The …
to hormones and neurotransmitters as well as the senses of sight, olfaction and taste. The …
Structure of a nanobody-stabilized active state of the β2 adrenoceptor
SGF Rasmussen, HJ Choi, JJ Fung, E Pardon… - Nature, 2011 - nature.com
G protein coupled receptors (GPCRs) exhibit a spectrum of functional behaviours in response
to natural and synthetic ligands. Recent crystal structures provide insights into inactive …
to natural and synthetic ligands. Recent crystal structures provide insights into inactive …
Activation and allosteric modulation of a muscarinic acetylcholine receptor
Despite recent advances in crystallography and the availability of G-protein-coupled receptor
(GPCR) structures, little is known about the mechanism of their activation process, as only …
(GPCR) structures, little is known about the mechanism of their activation process, as only …
A general protocol for the generation of Nanobodies for structural biology
E Pardon, T Laeremans, S Triest, SGF Rasmussen… - Nature protocols, 2014 - nature.com
There is growing interest in using antibodies as auxiliary tools to crystallize proteins. Here we
describe a general protocol for the generation of Nanobodies to be used as crystallization …
describe a general protocol for the generation of Nanobodies to be used as crystallization …
Nanobodies to study protein conformational states
… Author links open overlay panel Tomasz Uchański 1 2 , Els Pardon 1 2 , Jan Steyaert 1 2 …
Els Pardon: Writing - review & editing. Jan Steyaert: Writing - review & editing. …
Els Pardon: Writing - review & editing. Jan Steyaert: Writing - review & editing. …
Mutations in PMM2, a phosphomannomutase gene on chromosome 16p13 in carbohydrate-deficient glycoprotein type I syndrome (Jaeken syndrome)
Carbohydrate-deficient glycoprotein syndrome type 1 (CDG1 or Jaeken syndrome) is the
prototype of a class of genetic multisystem disorders characterized by defective glycosylation of …
prototype of a class of genetic multisystem disorders characterized by defective glycosylation of …
GABAA receptor signalling mechanisms revealed by structural pharmacology
…, D Karia, T Malinauskas, J Zivanov, E Pardon… - Nature, 2019 - nature.com
Type-A γ-aminobutyric (GABA A ) receptors are ligand-gated chloride channels with a very
rich pharmacology. Some of their modulators, including benzodiazepines and general …
rich pharmacology. Some of their modulators, including benzodiazepines and general …
[PDF][PDF] Structure of the nanobody-stabilized active state of the kappa opioid receptor
The κ-opioid receptor (KOP) mediates the actions of opioids with hallucinogenic, dysphoric,
and analgesic activities. The design of KOP analgesics devoid of hallucinatory and …
and analgesic activities. The design of KOP analgesics devoid of hallucinatory and …
Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation
G-protein-coupled receptors (GPCRs) modulate many physiological processes by
transducing a variety of extracellular cues into intracellular responses. Ligand binding to an …
transducing a variety of extracellular cues into intracellular responses. Ligand binding to an …
Cryo-EM structure of the human α1β3γ2 GABAA receptor in a lipid bilayer
…, WJ Stec, T Malinauskas, J Zivanov, E Pardon… - Nature, 2019 - nature.com
Type A γ-aminobutyric acid (GABA A ) receptors are pentameric ligand-gated ion channels
and the main drivers of fast inhibitory neurotransmission in the vertebrate nervous system 1 , …
and the main drivers of fast inhibitory neurotransmission in the vertebrate nervous system 1 , …