The classification of epithelial ovarian cancer has been substantially revised, with an increased
appreciation of the cellular origins and molecular aberrations of the different histotypes. …

Ovarian cancer represents the fourth most frequent type of cancer among females and is the
leading cause of death from gynecological cancer in the western world. This review …

Epithelial ovarian cancer is the most common cause of death from gynecological malignancies
in the Western world. The overall 5-year survival is only 30% due to late diagnosis and …

Background Genome-wide measures of gene expression can identify patterns of gene activity
that subclassify tumours and might provide a better means than is currently available for …

Epithelial ovarian cancer is a highly heterogeneous disease and remains the most lethal
gynaecological malignancy in the Western world. Therapeutic approaches need to account for …

Background Estrogen receptor positive (ER+) breast cancers (BC) are heterogeneous with
regard to their clinical behavior and response to therapies. The ER is currently the best …

… Address reprint requests to Els Berns, … Klijn JG, Berns EM, Foekens JA: Other
endocrine and biological agents in the treatment of advanced breast cancer, in Miller WR …

TP53 has been implicated in regulation of the cell cycle,DNA repair, and apoptosis. We studied,
in primary breast tumors through direct cDNA sequencing of exons 2–11, whether TP53 …

Purpose: We previously discovered an extracellular matrix (ECM) gene cluster associated
with resistance to first-line tamoxifen therapy of patients with metastatic breast cancer. In this …

Amplification of the c-myc and HER2/neu genes was found in 20 and 23%, respectively, of
primary breast cancer tissues derived from 282 patients (median follow-up, 74 months). c-myc …