Transgenic mouse lines are invaluable tools for neuroscience but, as with any technique,
care must be taken to ensure that the tool itself does not unduly affect the system under study. …

Research in neuroscience increasingly relies on the mouse, a mammalian species that affords
unparalleled genetic tractability and brain atlases. Here, we introduce high-yield methods …

In many behavioral tasks, cortex enters a desynchronized state where low-frequency
fluctuations in population activity are suppressed. The precise behavioral correlates of …

The larval zebrafish is a popular model for translational research into neurological and
psychiatric disorders due to its conserved vertebrate brain structures, ease of genetic and …

… I, Elina Alexandra Katariina Jacobs, confirm that the work presented in this thesis is my
own. Where information has been derived from other sources, I confirm that this has been …

Population isolates such as those in Finland benefit genetic research because deleterious
alleles are often concentrated on a small number of low-frequency variants (0.1% ≤ minor …

Plasmodium ookinete invasion of the mosquito midgut is a crucial step of the parasite life cycle
but little is known about the molecular mechanisms involved. Previously, a phage display …

Coffee, a major dietary source of caffeine, is among the most widely consumed beverages in
the world and has received considerable attention regarding health risks and benefits. We …

Background Treatment of Diffuse Large B Cell Lymphoma (DLBCL) patients with rituximab
and the CHOP treatment regimen is associated with frequent intrinsic and acquired resistance…

… MF Jacobs reports grants from NIH during the conduct of the study. KA Janeway reports
personal fees from Bayer, Ipsen, Foundation Medicine, and personal fees from Takeda outside …