It is well established that autism spectrum disorders (ASD) have a strong genetic component;
however, for at least 70% of cases, the underlying genetic cause is unknown 1 . Under the …

The topology of metabolic networks may provide important insights not only into the metabolic
capacity of species, but also into the habitats in which they evolved. Here we introduce the …

The human microbiome plays a key role in a wide range of host-related processes and has
a profound effect on human health. Comparative analyses of the human microbiome have …

Autism spectrum disorder (ASD) manifests as alterations in complex human behaviors including
social communication and stereotypies. In addition to genetic risks, the gut microbiome …

Within each bacterial species, different strains may vary in the set of genes they encode or
in the copy number of these genes. Yet, taxonomic characterization of the human microbiota …

The human microbiome plays a key role in human health and is associated with numerous
diseases. Metagenomic-based studies are now generating valuable information about the …

Exome sequencing studies of autism spectrum disorders (ASDs) have identified many de
novo mutations but few recurrently disrupted genes. We therefore developed a modified …

The combinatorial cross-regulation of hundreds of sequence-specific transcription factors (TFs)
defines a regulatory network that underlies cellular identity and function. Here we use …

Despite considerable genetic heterogeneity underlying neurodevelopmental diseases, there
is compelling evidence that many disease genes will map to a much smaller number of …

The basic body plan and major physiological axes have been highly conserved during
mammalian evolution, yet only a small fraction of the human genome sequence appears to be …