The X chromosome and X-linked variants have largely been ignored in genome-wide and
candidate association studies of infectious diseases due to the complexity of statistical …

The evidence for a human genetic component in susceptibility to tuberculosis (TB) is
incontrovertible. Quite apart from studies of rare disease events illustrating the importance of key …

Interferon γ is believed to be crucial for host defence against many infections. To test the
hypothesis that a polymorphism in the gene for interferon γ (IFNG) is associated with …

Admixed populations present unique opportunities to discover the genetic factors underlying
many multifactorial diseases. The geographical position and complex history of South …

Background Tuberculosis, which is caused by Mycobacterium tuberculosis, remains one of
the leading causes of mortality worldwide. The C-type lectin DC-SIGN is known to be the …

The worldwide burden of tuberculosis (TB) remains an enormous problem, and is particularly
severe in the admixed South African Coloured (SAC) population residing in the Western …

Approximately 20% of persons living in areas hyperendemic for tuberculosis (TB) display
persistent lack of tuberculin skin test (TST) reactivity and appear to be naturally resistant to …

The historical impression that tuberculosis was an inherited disorder has come full circle
and substantial evidence now exists of the human genetic contribution to susceptibility to …

Approximately 15 genes have been directly associated with skin pigmentation variation in
humans, leading to its characterization as a relatively simple trait. However, by assembling a …

The study of recently admixed populations provides unique tools for understanding recent
population dynamics, socio-cultural factors associated with the founding of emerging …