Cytokines are secreted proteins that regulate important cellular responses such as
proliferation and differentiation 1 . Key events in cytokine signal transduction are well defined: …

Embryonic stem (ES) cells, the totipotent outgrowths of bias-tocysts 1,2 , can be cultured and
manipulated in vitro and then returned to the embryonic environment where they develop …

Mixed lineage kinase domain-like (MLKL) is a component of the "necrosome," the multiprotein
complex that triggers tumor necrosis factor (TNF)-induced cell death by necroptosis. To …

Cytokines regulate the growth and differentiation of cells by binding to cell-surface receptors
and activating intracellular signal transduction cascades such as the JAK-STAT pathway. …

Members of the suppressor of cytokine signaling (SOCS) family are potentially key physiological
negative regulators of interleukin-6 (IL-6) signaling. To examine whether SOCS3 is …

Mice lacking suppressor of cytokine signaling-1 (SOCS1) develop a complex fatal neonatal
disease. In this study, SOCS1 −/− mice were shown to exhibit excessive responses typical of …

Many cytokines exert their biological effect through members of the hemopoietin receptor
family. Using degenerate oligonucleotides to the common WSXWS motif, we have cloned from …

The four members of the recently identified suppressor of cytokines signaling family (SOCS-1,
SOCS-2, SOCS-3, and CIS, where CIS is cytokine-inducible SH2-containing protein) …

▪ Abstract Cytokines are an integral component of the adaptive and innate immune responses.
The signaling pathways triggered by the engagement of cytokines with their specific cell …

The suppressors of cytokine signaling (SOCS) family of proteins act as intracellular inhibitors
of several cytokine signal transduction pathways. Their expression is induced by cytokine …