Estimating the time of delivery is of high clinical importance because pre- and postterm
deviations are associated with complications for the mother and her offspring. However, current …

Cellular organization and functions encompass multiple scales in vivo. Emerging high-plex
imaging technologies are limited in resolving subcellular biomolecular features. Expansion …

Adoption of high-content omic technologies in clinical studies, coupled with computational
methods, has yielded an abundance of candidate biomarkers. However, translating such …

Pregnancy requires a delicate immune balance that nurtures the allogeneic fetus, while
maintaining reactivity against pathogens. Despite increasing knowledge, data is lacking on the …

The emergence of regulatory T cells (Tregs) as central mediators of peripheral tolerance in
the immune system has led to an important area of clinical investigation to target these cells …

High-throughput single-cell analysis technologies produce an abundance of data that is
critical for profiling the heterogeneity of cellular systems. We introduce VoPo ( https://github.com/…

Preeclampsia is a complex disease of pregnancy whose physiopathology remains unclear.
We developed machine-learning models for early prediction of preeclampsia (first 16 weeks …

STUDY QUESTION Is the natural killer (NK) cell receptor repertoire of endometrial NK (eNK)
cells tissue-specific? SUMMARY ANSWER The NK cell receptor (NKR) expression profile …

The biological determinants underlying the range of coronavirus 2019 (COVID-19) clinical
manifestations are not fully understood. Here, over 1,400 plasma proteins and 2,600 single-…

Although most causes of death and morbidity in premature infants are related to immune
maladaptation, the premature immune system remains poorly understood. We provide a …