Most of the inducible mutagenesis observed in Escherichia coli after treatment with many
DNA damaging agents is dependent upon the products of the umuD,C operon. RecA-mediated …

DNA damage-inducible mutagenesis in Escherichia coli is largely dependent upon the
activity of the UmuD (UmuD') and UmuC proteins. The intracellular level of these proteins is …

We have studied homologous recombination in a derivative of phage λ containing two 1.4-kb
repeats in inverted orientation. Inversion of the intervening 2.5-kb segment occurred …

Human infection by Mycobacterium tuberculosis is endemic, with approximately 2 billion
infected and is the most common cause of adult death due to an infectious agent. Because of …

Over the past several decades, a number of fish species, including the zebrafish, medaka,
and platyfish/swordtail, have become important models for human health and disease. …

Mycobacterial infections in laboratory zebrafish Danio rerio are common and widespread in
research colonies. Mycobacteria within free-living amoebae have been shown to be …

Induction of the Escherichia coli SOS system increases the ability of the cells to perform DNA
repair and mutagenesis. Previous work has shown that this increased mutagenesis is the …

Waterborne pathogenic mycobacteria can form biofilms, and certain species can cause hard-to-treat
human lung infections. Astronaut health could therefore be compromised if the …

Mycobacterium marinum is the causative agent for the tuberculosis-like disease mycobacteriosis
in fish and skin lesions in humans. Ubiquitous in its geographical distribution, M. …

The Escherichia coli RecA protein has at least three roles in SOS mutagenesis: (1)
derepression of the SOS regulon by mediating LexA cleavage; (2) activation of the UmuD …