Astrocytes actively participate in synaptic integration by releasing transmitter (glutamate) via
a calcium-regulated, exocytosis-like process. Here we show that this process follows …

Emergence of SARS-CoV-2 causing COVID-19 has resulted in hundreds of thousands of
deaths. In search for key targets of effective therapeutics, robust animal models mimicking …

Bicyclams are a novel class of antiviral compounds that are highly potent and selective
inhibitors of the replication of HIV-1 and HIV-2. Surprisingly, however, when the prototype …

A rapid, sensitive and automated assay procedure was developed for the in vitro evaluation
of anti-HIV agents. An HTLV-I transformed T4-cell line, MT-4, which was previously shown …

The expanding pandemic of coronavirus disease 2019 (COVID-19) requires the development
of safe, efficacious and fast-acting vaccines. Several vaccine platforms are being …

IN the search for compounds active against human immunodeficiency virus (HIV), we have
found that members of a novel series of tetrahydro-imidazo[4,5,1-jk][l,4]-benzodiazepin-2(1H)-…

The bicyclam AMD3100 (formula weight 830) blocks HIV-1 entry and membrane fusion via
the CXCR4 co-receptor, but not via CCR5. AMD3100 prevents monoclonal antibody 12G5 …

This study was undertaken to demonstrate the unique specificity of the chemokine receptor
CXCR4 antagonist AMD3100. Calcium flux assays with selected chemokine/cell …

AMD3100 is a CXCR4 receptor inhibitor with anti–HIV-1 activity in vitro. We tested the safety,
pharmacokinetics, and antiviral effect of AMD3100 administered for 10 days by continuous …

The (S)- and (R)-enantiomers of acyclic purine nucleoside phosphonate analogs (ie, 3-hydroxy-2-phosphonomethoxypropyl
[HPMP] derivatives, 3-fluoro-2-phosphonomethoxypropyl […