G1/S cell cycle blockers and inhibitors of cyclin-dependent kinases suppress camptothecin-induced neuronal apoptosis
Previous studies have demonstrated that G1/S cell cycle blockers and inhibitors of cyclin-dependent
kinases (CDKs) prevent the death of nerve growth factor (NGF)-deprived PC12 cells …
kinases (CDKs) prevent the death of nerve growth factor (NGF)-deprived PC12 cells …
[HTML][HTML] The QT interval in patients with COVID-19 treated with hydroxychloroquine and azithromycin
…, A Aizer, D Holmes, S Bernstein, M Spinelli, DS Park… - Nature medicine, 2020 - nature.com
To the Editor—The SARS-CoV-2 pandemic has caused more than 1.6 million positive cases
and more than 95,000 confirmed deaths as of 10 April 2020 (ref. 1). Although there are no …
and more than 95,000 confirmed deaths as of 10 April 2020 (ref. 1). Although there are no …
Caveolin, caveolae, and endothelial cell function
Caveolae are 50- to 100-nm cell-surface plasma membrane invaginations observed in
terminally differentiated cells. They are particularly abundant in endothelial cells, where they are …
terminally differentiated cells. They are particularly abundant in endothelial cells, where they are …
Involvement of interferon-γ in microglial-mediated loss of dopaminergic neurons
Growing evidence implicates microglia in the loss of dopaminergic neurons in Parkinson's
disease (PD). However, factors mediating microglial activation in PD are poorly understood. …
disease (PD). However, factors mediating microglial activation in PD are poorly understood. …
[HTML][HTML] Caveolin-1-deficient mice are lean, resistant to diet-induced obesity, and show hypertriglyceridemia with adipocyte abnormalities
Caveolae organelles and caveolin-1 protein expression are most abundant in adipocytes and
endothelial cells. Our initial report on mice lacking caveolin-1 (Cav-1) demonstrated a loss …
endothelial cells. Our initial report on mice lacking caveolin-1 (Cav-1) demonstrated a loss …
Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death
Caspase-independent death mechanisms have been shown to execute apoptosis in many
types of neuronal injury. P53 has been identified as a key regulator of neuronal cell death …
types of neuronal injury. P53 has been identified as a key regulator of neuronal cell death …
Programmed cell death in Parkinson's disease
K Venderova, DS Park - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
Parkinson's disease is a debilitating disorder characterized by a progressive loss of dopaminergic
neurons caused by programmed cell death. The aim of this review is to provide an up-…
neurons caused by programmed cell death. The aim of this review is to provide an up-…
[HTML][HTML] Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases
…, M Salvucci, I Llorente-Folch, DS Park… - Cell Death & …, 2018 - nature.com
Neurodegenerative diseases are a spectrum of chronic, debilitating disorders characterised
by the progressive degeneration and death of neurons. Mitochondrial dysfunction has been …
by the progressive degeneration and death of neurons. Mitochondrial dysfunction has been …
Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease
…, S Przedborski, H Anisman, DS Park - Proceedings of the …, 2003 - National Acad Sciences
Recent evidence indicates that cyclin-dependent kinases (CDKs, cdks) may be inappropriately
activated in several neurodegenerative conditions. Here, we report that cdk5 expression …
activated in several neurodegenerative conditions. Here, we report that cdk5 expression …
The cardiac conduction system
DS Park, GI Fishman - Circulation, 2011 - Am Heart Assoc
The human heart beats 2.5 billion times during a normal lifespan, a feat accomplished by
cells of the cardiac conduction system (CCS). The functional components of the CCS can be …
cells of the cardiac conduction system (CCS). The functional components of the CCS can be …