Myocardial infarction, stroke, and sepsis trigger systemic inflammation and organism-wide
complications that are difficult to manage. Here, we examined the contribution of …

Sudden cardiac death, arising from abnormal electrical conduction, occurs frequently in
patients with coronary heart disease. Myocardial ischemia simultaneously induces arrhythmia …

Background Neutrophils are thought to be short‐lived first responders to tissue injuries such
as myocardial infarction (MI), but little is known about their diversification or dynamics. …

Conclusions These results define the single cell transcriptomes underlying hepatic inflammation
and fibrosis precipitated by NLRP3 activation. Clinically, our data support the notion that …

Sterile tissue injury is thought to locally activate innate immune responses via damage-associated
molecular patterns (DAMPs). Whether innate immune pathways are remotely …

Introduction The type I interferon (IFN) response is an innate immune program that mediates
anti-viral, anti-cancer, auto-immune, auto-inflammatory, and sterile injury responses. Bone …

Cell communication underlies emergent functions in diverse cell types and tissues. Recent
evidence suggests that macrophages are organized in communicating networks, but new …

Sterile tissue injury recruits myeloid cells (neutrophils and monocytes) from the bone marrow
by stimulating a process known as emergency myelopoiesis. It is commonly assumed that …

Sterile tissue injury recruits myeloid cells (neutrophils and monocytes) from the bone marrow
by stimulating a process known as emergency myelopoiesis. It is commonly assumed that …

Myocardial infarction (MI) elicits a rapid and vigorous reaction from the bone marrow
hematopoietic compartment, inducing a massive efflux of myeloid first responders into the …