Transposable elements are viewed as ‘selfish genetic elements’, yet they contribute to gene
regulation and genome evolution in diverse ways 1 . More than half of the human genome …

We present GraphProt, a computational framework for learning sequence- and structure-binding
preferences of RNA-binding proteins (RBPs) from high-throughput experimental data. …

Dosage compensation in Drosophila is an epigenetic phenomenon utilizing proteins and
long noncoding RNAs (lncRNAs) for transcriptional upregulation of the male X chromosome. …

Determining the structural properties of mRNA is key to understanding vital post-transcriptional
processes. As experimental data on mRNA structure are scarce, accurate structure …

The CRISPR arrays found in many bacteria and most archaea are transcribed into a long
precursor RNA that is processed into small clustered regularly interspaced short palindromic …

Haematopoietic stem cells (HSCs) are normally quiescent, but have evolved mechanisms to
respond to stress. Here, we evaluate haematopoietic regeneration induced by …

Tissue-specific alternative splicing is critical for the emergence of tissue identity during
development, yet the role of this process in malignant transformation is undefined. Tissue-specific …

Alternative splicing generates distinct mRNA isoforms and is crucial for proteome diversity
in eukaryotes. The RNA-binding protein (RBP) U2AF2 is central to splicing decisions, as it …

About half of mammalian miRNA genes lie within introns of protein-coding genes, yet little is
known about functional interactions between miRNAs and their host genes. The intronic …

RNA-binding proteins (RBPs) play important and essential roles in eukaryotic gene
expression regulating splicing, localization, translation, and stability of mRNAs. We describe …