fy this observation, we extracted the maximum of the post-stimulus signal in the five most
responsive regions in both experiments. In 2P imaging, all regions displayed a substantial …

Fitness landscapes 1 , 2 depict how genotypes manifest at the phenotypic level and form the
basis of our understanding of many areas of biology 2 , 3 , 4 , 5 , 6 , 7 , yet their properties …

Despite the growing number of immune repertoire sequencing studies, the field still lacks
software for analysis and comprehension of this high-dimensional data. Here we report …

The decrease of TCR diversity with aging has never been studied by direct methods. In this
study, we combined high-throughput Illumina sequencing with unique cDNA molecular …

Deep profiling of antibody and T cell–receptor repertoires by means of high-throughput
sequencing has become an attractive approach for adaptive immunity studies, but its power is …

For understanding the rules and laws of adaptive immunity, high‐throughput profiling of T‐cell
receptor ( TCR ) repertoires becomes a powerful tool. The structure of TCR repertoires is …

To the Editor: Somatic recombination and accumulation of mutations in VDJ segments result
in vast heterogeneity of T-cell receptor (TCR) and immunoglobulin repertoires1, 2. High-…

Background The Immunoglobulins (IG) and the T cell receptors (TR) play the key role in
antigen recognition during the adaptive immune response. Recent progress in next-generation …

The TCR repertoire is a mirror of the human immune system that reflects processes caused
by infections, cancer, autoimmunity, and aging. Next generation sequencing (NGS) is …

The transfer of T cell receptor (TCR) genes into patient T cells is a promising approach for
the treatment of both viral infections and cancer. Although efficient methods exist to identify …