β‐Thalassemia intermediate patients show a remarkable clinical heterogeneity. We examined
the phenotypic diversity of 950 β‐thalassemia/Hb E patients in an attempt to construct a …

10.7554/eLife.41337.001 CRISPR/Cas9-based genome editing has yet to be reported in
species of the Platyhelminthes. We tested this approach by targeting omega-1 (ω1) of …

β-Thalassemia/Hb E patients show a range of clinical severities, from nearly asymptomatic
to transfusion-dependent thalassemia major. This study investigated the clinical …

In macrophages, cellular iron metabolism status is tightly integrated with macrophage
phenotype and associated with mitochondrial function. However, how molecular events regulate …

The hydroxycarbamide (HC)‐inducible small guanosine triphosphate (GTP)‐binding protein,
secretion‐associated and RAS‐related (SAR) protein has recently been shown to play a …

Monocyte migration requires the dynamic redistribution of integrins through a regulated
endo-exocytosis cycle, but the complex molecular mechanisms underlying this process have not …

Hydroxyurea (HU) is effectively used in the management of β-hemoglobinopathies by
augmenting the production of fetal hemoglobin (HbF). However, the molecular mechanisms …

Increased fetal hemoglobin expression in adulthood is associated with acute stress erythropoiesis.
However, the mechanisms underlying γ-globin induction during the rapid expansion …

Human immunodeficiency virus type 1 (HIV-1) vectors can transduce human hematopoietic
stem cells (HSC), but transduction efficiency varies among individuals. The innate immune …

Crosstalk between malignant and neighboring cells contributes to tumor growth. In East Asia,
infection with the liver fluke is a major risk factor for cholangiocarcinoma (CCA). The liver …