Regulatory landscapes have been defined in vertebrates as large DNA segments containing
diverse enhancer sequences that produce coherent gene transcription. These genomic …

Developmental genes are often controlled by large regulatory landscapes matching topologically
associating domains (TADs). In various contexts, the associated chromatin backbone …

Vertebrate Hox genes are critical for the establishment of structures during the development
of the main body axis. Subsequently, they play important roles either in organizing …

In all tetrapods examined thus far, the development and patterning of limbs require the
activation of gene members of the HoxD cluster. In mammals, they are regulated by a complex …

Mammalian genomes are partitioned into sub-megabase to megabase-sized units of
preferential interactions called topologically associating domains or TADs, which are likely …

Modifications in gene regulation are driving forces in the evolution of organisms. Part of these
changes involve cis-regulatory elements (CREs), which contact their target genes through …

The expression of some genes depends on large, adjacent regions of the genome that
contain multiple enhancers. These regulatory landscapes frequently align with Topologically …

Human families with chromosomal rearrangements at 2q31, where the human HOXD locus
maps, display mesomelic dysplasia, a severe shortening and bending of the limb. In mice, …

The evolutionarily conserved transcription factor, Tbx18, is expressed in a dynamic pattern
throughout embryonic and early postnatal life and plays crucial roles in the development of …

The current pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
has affected most of the world in a profound way. As an indirect consequence, the …