Digital production, transmission and storage have revolutionized how we access and use
information but have also made archiving an increasingly complex task that requires active, …

Phylogenetic inference and evaluating support for inferred relationships is at the core of many
studies testing evolutionary hypotheses. Despite the popularity of nonparametric bootstrap …

Approximate Bayesian computation (ABC) constitutes a class of computational methods
rooted in Bayesian statistics . In all model-based statistical inference , the likelihood function is …

The biological interpretation of gene lists with interesting shared properties, such as up-or
down-regulation in a particular experiment, is typically accomplished using gene ontology …

Recent research into structural variants (SVs) has established their importance to medicine
and molecular biology, elucidating their role in various diseases, regulation of gene …

Large structural variations (SVs) within genomes are more challenging to identify than smaller
genetic variants but may substantially contribute to phenotypic diversity and evolution. We …

Accurate genome-wide identification of orthologs is a central problem in comparative
genomics, a fact reflected by the numerous orthology identification projects developed in recent …

Background A major bottleneck in our understanding of the molecular underpinnings of life
is the assignment of function to proteins. While molecular experiments provide the most …

… Christophe Dessimoz Christophe Dessimoz is a post-doc and lecturer in the CBRG group,
computer science, ETH Zurich. He strives to understand the forces that shape genes, …

Background The Critical Assessment of Functional Annotation (CAFA) is an ongoing, global,
community-driven effort to evaluate and improve the computational annotation of protein …