The plasma proteome is the ultimate target for biomarker discovery. It stores an endless
amount of information on the pathophysiological status of a living organism, which is, however, …

Creating in vitro models of diseases of the pancreatic ductal compartment requires a
comprehensive understanding of the developmental trajectories of pancreas-specific cell types. …

To date, the proteomic profiling of Müller cells, the dominant macroglia of the retina, has
been hampered because of the absence of suitable enrichment methods. We established a …

To better understand the involvement of retinal Müller glial (RMG) cells in retinal diseases,
we phenotyped primary porcine RMGs in dependence of cultivation time using different …

Carefully orchestrated intercellular communication is an essential prerequisite for the development
of multicellular organisms. In recent years, tunneling nanotubes (TNT) have emerged …

Genome-wide association studies (GWAS) identified the MEIS1 locus for Restless Legs
Syndrome (RLS), but causal single nucleotide polymorphisms (SNPs) and their functional …

Ragweed pollen is the main cause of allergenic diseases in Northern America, and the
weed has become a spreading neophyte in Europe. Climate change and air pollution are …

To better understand molecular mechanisms regulating changes in metabolism, as observed
eg in diabetes or neuronal disorders, the function of mitochondria needs to be precisely …

Background/purpose of the study Epidemiological evidence suggests that low doses of ionising
radiation (≤1.0 Gy) produce persistent alterations in cognition if the exposure occurs at …

Background & Aims In Wilson disease, ATP7B mutations impair copper excretion into bile.
Hepatic copper accumulation may induce mild to moderate chronic liver damage or even …