User profiles for Chris Grant
 | Chris GrantProfessor of Biochemistry, University of Manchester Verified email at manchester.ac.uk Cited by 11415 |
The Response to Heat Shock and Oxidative Stress in Saccharomyces cerevisiae
A common need for microbial cells is the ability to respond to potentially toxic environmental
insults. Here we review the progress in understanding the response of the yeast …
insults. Here we review the progress in understanding the response of the yeast …
Role of the glutathione/glutaredoxin and thioredoxin systems in yeast growth and response to stress conditions
CM Grant - Molecular microbiology, 2001 - Wiley Online Library
Sulphydryl groups (‐SH) play a remarkably broad range of roles in the cell, and the redox
status of cysteine residues can affect both the structure and the function of numerous enzymes, …
status of cysteine residues can affect both the structure and the function of numerous enzymes, …
[HTML][HTML] Global translational responses to oxidative stress impact upon multiple levels of protein synthesis
Global inhibition of protein synthesis is a common response to stress conditions. We have
analyzed the regulation of protein synthesis in response to oxidative stress induced by …
analyzed the regulation of protein synthesis in response to oxidative stress induced by …
Glutathione is an essential metabolite required for resistance to oxidative stress in the yeastSaccharomyces cerevisiae
CM Grant, FH MacIver, IW Dawes - Current genetics, 1996 - Springer
Glutathione (GSH) is an abundant cellular thiol which has been implicated in numerous
cellular processes and in protection against stress caused by xenobiotics, carcinogens and …
cellular processes and in protection against stress caused by xenobiotics, carcinogens and …
Protein S-thiolation targets glycolysis and protein synthesis in response to oxidative stress in the yeast Saccharomyces cerevisiae
D Shenton, CM Grant - Biochemical Journal, 2003 - portlandpress.com
The irreversible oxidation of cysteine residues can be prevented by protein S-thiolation, a
process by which protein SH groups form mixed disulphides with low-molecular-mass thiols …
process by which protein SH groups form mixed disulphides with low-molecular-mass thiols …
Short‐course versus prolonged‐course antibiotic therapy for hospital‐acquired pneumonia in critically ill adults
R Pugh, C Grant, RPD Cooke… - Cochrane Database of …, 2011 - cochranelibrary.com
Background Pneumonia is the most common hospital‐acquired infection affecting patients in
the intensive care unit (ICU). However, the optimal duration of antibiotic therapy for hospital…
the intensive care unit (ICU). However, the optimal duration of antibiotic therapy for hospital…
The Yeast Saccharomyces cerevisiae Contains Two Glutaredoxin Genes That Are Required for Protection against Reactive Oxygen Species
…, G Perrone, IW Dawes, CM Grant - Molecular biology of the …, 1998 - Am Soc Cell Biol
Glutaredoxins are small heat-stable proteins that act as glutathione-dependent disulfide
oxidoreductases. Two genes, designatedGRX1 and GRX2, which share 40–52% identity and 61…
oxidoreductases. Two genes, designatedGRX1 and GRX2, which share 40–52% identity and 61…
Yeast glutathione reductase is required for protection against oxidative stress and is a target gene for yAP‐1 transcriptional regulation
Glutathione (GSH) is an abundant cellular thiol which has been implicated in many cellular
processes including protection against xenobiotics, carcinogens and free radicals. Utilization …
processes including protection against xenobiotics, carcinogens and free radicals. Utilization …
Glutathione synthetase is dispensable for growth under both normal and oxidative stress conditions in the yeast Saccharomyces cerevisiae due to an accumulation of …
CM Grant, FH MacIver, IW Dawes - Molecular biology of the cell, 1997 - Am Soc Cell Biol
Glutathione (GSH) synthetase (Gsh2) catalyzes the ATP-dependent synthesis of GSH from
gamma-glutamylcysteine (gamma-Glu-Cys) and glycine. GSH2, encoding the …
gamma-glutamylcysteine (gamma-Glu-Cys) and glycine. GSH2, encoding the …
Glutathione and catalase provide overlapping defenses for protection against hydrogen peroxide in the yeastsaccharomyces cerevisiae
CM Grant, G Perrone, IW Dawes - Biochemical and biophysical research …, 1998 - Elsevier
Glutathione (GSH) is an abundant and ubiquitous low-molecular-weight thiol which has
proposed roles in many cellular processes including protection against the deleterious effects of …
proposed roles in many cellular processes including protection against the deleterious effects of …