Clinical metagenomic next-generation sequencing (mNGS), the comprehensive analysis of
microbial and host genetic material (DNA and RNA) in samples from patients, is rapidly …

An outbreak of betacoronavirus severe acute respiratory syndrome (SARS)-CoV-2 began in
Wuhan, China in December 2019. COVID-19, the disease associated with SARS-CoV-2 …

Nearly all infectious agents contain DNA or RNA genomes, making sequencing an
attractive approach for pathogen detection. The cost of high-throughput or next-generation …

We identified an emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
variant by viral whole-genome sequencing of 2,172 nasal/nasopharyngeal swab samples …

<p id="p001">A 14-year-old boy with severe combined immunodeficiency presented three
times to a medical facility over a period of 4 months with fever and headache that progressed …

Background Metagenomic next-generation sequencing (NGS) of cerebrospinal fluid (CSF)
has the potential to identify a broad range of pathogens in a single test. Methods In a 1-year, …

We developed a metagenomic next-generation sequencing (mNGS) test using cell-free DNA
from body fluids to identify pathogens. The performance of mNGS testing of 182 body fluids …

SARS-CoV-2 Delta and Omicron are globally relevant variants of concern. Although individuals
infected with Delta are at risk of developing severe lung disease, infection with Omicron …

Rapidly emerging SARS-CoV-2 variants jeopardize antibody-based countermeasures.
Although cell culture experiments have demonstrated a loss of potency of several anti-spike …

Transmission of Zika virus (ZIKV) in the Americas was first confirmed in May 2015 in northeast
Brazil 1 . Brazil has had the highest number of reported ZIKV cases worldwide (more than …