[HTML][HTML] The relationship between the gut microbiome and metformin as a key for treating type 2 diabetes mellitus
CB Lee, SU Chae, SJ Jo, UM Jerng… - International journal of …, 2021 - mdpi.com
Metformin is the first-line pharmacotherapy for treating type 2 diabetes mellitus (T2DM);
however, its mechanism of modulating glucose metabolism is elusive. Recent advances have …
however, its mechanism of modulating glucose metabolism is elusive. Recent advances have …
Nanoparticle phototherapy in the era of cancer immunotherapy
Phototherapy, including photodynamic therapy (PDT) and photothermal therapy (PTT),
exploits light to activate photoreactions that kill cancer cells. Recent studies show that …
exploits light to activate photoreactions that kill cancer cells. Recent studies show that …
Nanoparticle‐laden macrophages for tumor‐tropic drug delivery
Macrophages hold great potential in cancer drug delivery because they can sense chemotactic
cues and home to tumors with high efficiency. However, it remains a challenge to load …
cues and home to tumors with high efficiency. However, it remains a challenge to load …
[HTML][HTML] Clinical Pharmacokinetics of Approved RNA Therapeutics
SJ Jo, SU Chae, CB Lee, SK Bae - International Journal of Molecular …, 2023 - mdpi.com
RNA-mediated drugs are a rapidly growing class of therapeutics. Over the last five years,
the list of FDA-approved RNA therapeutics has expanded owing to their unique targets and …
the list of FDA-approved RNA therapeutics has expanded owing to their unique targets and …
Nanoparticles encapsulating nitrosylated maytansine to enhance radiation therapy
Radiotherapy remains a major treatment modality for cancer types such as non-small cell
lung carcinoma (or NSCLC). To enhance treatment efficacy at a given radiation dose, …
lung carcinoma (or NSCLC). To enhance treatment efficacy at a given radiation dose, …
[HTML][HTML] Image-guided selection of Gd@ C-dots as sensitizers to improve radiotherapy of non-small cell lung cancer
Background Recently, gadolinium-intercalated carbon dots (Gd@C-dots) have demonstrated
potential advantages over traditional high-Z nanoparticles (HZNPs) as radiosensitizers due …
potential advantages over traditional high-Z nanoparticles (HZNPs) as radiosensitizers due …
[HTML][HTML] Radiodynamic therapy with CsI (na)@ MgO nanoparticles and 5-aminolevulinic acid
Background Radiodynamic therapy (RDT) holds the potential to overcome the shallow tissue
penetration issue associated with conventional photodynamic therapy (PDT). To this end, …
penetration issue associated with conventional photodynamic therapy (PDT). To this end, …
Ultrasmall Gd@ Cdots as a radiosensitizing agent for non-small cell lung cancer
High-Z nanoparticles (HZNPs) afford high cross-section for high energy radiation and have
attracted wide attention as a novel type of radiosensitizer. However, conventional HZNPs are …
attracted wide attention as a novel type of radiosensitizer. However, conventional HZNPs are …
[HTML][HTML] Ultrathin gold nanowires to enhance radiation therapy
Background Radiation therapy is a main treatment option for cancer. Due to normal tissue
toxicity, radiosensitizers are commonly used to enhance RT. In particular, heavy metal or high-…
toxicity, radiosensitizers are commonly used to enhance RT. In particular, heavy metal or high-…
Potassium Iodide Nanoparticles Enhance Radiotherapy against Breast Cancer by Exploiting the Sodium-Iodide Symporter
Iodine has shown promise in enhancing radiotherapy. However, conventional iodine compounds
show fast clearance and low retention inside cancer cells, limiting their application as a …
show fast clearance and low retention inside cancer cells, limiting their application as a …