Background Natural killer (NK) cells provide important immune protection from cancer and
are a key requirement for particular immunotherapies. There is accumulating evidence that …

Over the past 20 years, the management of gastrointestinal stromal tumors has acted as an
important model in the advancement of molecularly targeted therapies for solid tumors. The …

Introduction Anthracycline chemotherapeutic agents are widely used in the treatment of
hematological and solid tumors, working principally through DNA intercalation and …

Both randomized controlled trials (RCTs) and retrospective studies have shown that a
comprehensive geriatric assessment (CGA) prior to a patient commencing systemic anti-cancer …

Natural Killer (NK) cells provide important protection from cancer and are a key requirement
for particular immunotherapies. In activated NK cells, a metabolic response towards …

Background Older patients are underrepresented in the clinical trials that determine the
standards of care for oncological treatment. We conducted a review to identify whether there …

Introduction Geriatric oncology is a rapidly evolving field of practice, where comprehensive
geriatric assessments (CGA) and multidisciplinary team (MDT) input have the potential to …

Introduction The increase in statin use, since their introduction, has been rapid and the
broadening of indications has occurred seemingly without restriction. Once established on statin …

e21196 Background: Immunotherapy (IO) has improved outcomes of advanced NSCLC patients
in randomized clinical trials. Data on outcomes for these agents outside of a clinical trial …

11552 Background: Combining HT-RT with anti PD-L1 therapy may enhance local and distant
tumour control in mSTS. This was a Phase 1 trial to evaluate the safety, tolerability, and …