Canalicular secretion of bile salts is a vital function of the vertebrate liver, yet the molecular
identity of the involved ATP-dependent carrier protein has not been elucidated. We cloned …

The organic anion transporting polypeptides (rodents: Oatps, human: OATPs) form a superfamily
of sodium-independent transport systems that mediate the transmembrane transport of …

Background & Aims: Hepatic uptake of cholephilic organic compounds is mediated by members
of the organic anion-transporting polypeptide (OATP) family. We aimed to characterize …

Organic anion transporting polypeptides (Oatps/OATPs) form a growing gene superfamily
and mediate transport of a wide spectrum of amphipathic organic solutes. Different Oatps/…

The human organic anion and cation transporters are classified within two SLC superfamilies.
Superfamily SLCO (formerly SLC21A) consists of organic anion transporting polypeptides (…

Using expression cloning in Xenopus laevis oocytes, we have isolated a cDNA encoding a
rat liver organic anion-transporting polypeptide (oatp). The cloned oatp mediated Na(+)-…

Liver parenchymal cells continuously extract high amounts of bile acids from portal blood
plasma. This uptake process is mediated by a Na+/bile acid cotransport system. A cDNA …

We have used a cDNA probe from a cloned rat liver Na+/taurocholate cotransporting
polypeptide (Ntcp) to screen a human liver cDNA library. A 1,599-bp cDNA clone that encodes a …

Background & Aims : Based on a recently cloned rat liver organic anion transporter, we
attempted to clone the corresponding human liver organic anion transporting polypeptide. …

Microcystins are toxins produced by freshwater cyanobacteria. They are cyclic heptapeptides
that exhibit hepato- and neurotoxicity. However, the transport systems that mediate uptake …